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KMID : 0043319940170010021
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Archives of Pharmacal Research
1994 Volume.17 No. 1 p.21 ~ p.25
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Human Renal Dipeptidase from Kidneys of Renal Stone Patients: Partial Characterization
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Park Haeng-Soon
Kim Doh-Ha
Kwark Hyung S.Ellen
Park Sung-Kwang
Kang Sung-Kyew
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Abstract
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Physico-chemical characterization of human renal dipeptidase was carried out. It was a glycoprotein with a subunit MW of approximately 47,700 dalton. The pH optimum was at 8 and its stable conformation was retained between pH 5 and 12. The kinetic parameters determined with imipenem, a noval antibiotic, were Vmax, ; km, 4.35 mM ; and Ki with cilastatin, Cilastatin demonstrated reversible competitive inhibition.
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KEYWORD
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Renal dipeptidase (RDPase), lmipenem, Cilastatin, Glycyldehydrophenylalanine(Gdp)
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